Mutagenicity Characteristics of 255 Environmental Chemicals.

Mutagenicity Characteristics of 255 Environmental Chemicals

Faculty of Engineering Yokohama National University, 79–5 Tokiwadai, Hodogaya-ku, Yokohama 240–8501, Japan, Graduate School of Environment and Information Sciences, Yokohama National University, 79–7 Tokiwadai, Hodogaya-ku, Yokohama 240–8501, Japan, and Graduate School of Pharmaceutical Sciences, Kyushu University, 3–1–1 Maidashi, Higashiku, Fukuoka 812–8582, Japan (Received March 15, 2002; Acc...

Guidelines for the testing of chemicals for mutagenicity. Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment.

Environmental persistence of chemicals.

BACKGROUND The hazard criterion of persistence as it applies to chemicals in the environment is reviewed and discussed. This quantity can not be measured directly in the environment, thus it must be estimated using models that synthesise information on chemical half-lives and partitioning properties, the nature of the environment and how the chemical is released into the environment. MAIN FEA...

Epigenetics and environmental chemicals.

PURPOSE OF REVIEW Epigenetics investigates heritable changes in gene expression occurring without changes in DNA sequence. Several epigenetic mechanisms, including DNA methylation, histone modifications, and microRNA expression, can change genome function under exogenous influence. Here, we review current evidence indicating that epigenetic alterations mediate toxicity from environmental chemic...

Integrated strategy for mutagenicity prediction applied to food contact chemicals.

Food contamination due to unintentional leakage of chemicals from food contact materials (FCM) is a source of increasing concern. Since for many of these substances, only limited or no toxicological data are available, the development of alternative methodologies to establish rapidly and cost-efficiently level of safety concern is critical to ensure adequate consumer protection. Computational t...